DELIVERABLES Report on candidate mechanisms Download Report on IBS pattern comorbidities in retrospective cohorts Download Report on Identification of common genetic variants involved in IBS and comorbidities Download Report on IBS pattern comorbidities in prospectively deeply phenotyped cohort Download Report on data integration provided by ESM app and HumanITcare platform Download Report on fecal sampling and transport of IBS cohorts in the project and the quantitative microbiome profiling Download Report on microbiome and metabolome profiling in IBS and comorbid IBS Download Report on confirmation of transfer of comorbid IBS phenotypes from animal models and from human samples Download Report on mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer Download Report on candidate mechanisms and biomarkers for comorbid IBS Download Report on intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS Download Report on effect of approved drugs on candidate mechanisms Download Report on profiling of "gut-to-brain" and "brain-to-gut" mechanisms associated with comorbidities development in IBS Download