DELIVERABLES

Report on candidate mechanisms

Report on IBS pattern comorbidities in retrospective cohorts

Report on Identification of common genetic variants involved in IBS and comorbidities

Report on IBS pattern comorbidities in
prospectively deeply phenotyped cohort

Report on data integration provided by ESM app and HumanITcare platform

Report on fecal sampling and transport of IBS cohorts in the project and the quantitative microbiome profiling

Report on microbiome and metabolome profiling in IBS and comorbid IBS

Report on confirmation of transfer of comorbid IBS phenotypes from animal models and from human samples

Report on mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer

Report on candidate mechanisms and biomarkers for comorbid IBS

Report on intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS

Report on effect of approved drugs on candidate mechanisms

Report on profiling of "gut-to-brain" and "brain-to-gut" mechanisms associated with comorbidities development in IBS